Dec 2, 2019

Tim Noakes, MD, PhD and medical researcher, from Twitter:
“If this study’d been published when it should have been (circa 1976), it would have prevented all future studies in which dietary saturated fat was replaced with polyunsaturated fats. Or any other dietary attempts to lower blood cholesterol concentrations”
“Because it established that substituting polyunsaturated fats for dietary saturated fats caused harm especially to older men. Thus according to the ethical principle – First do no harm – it would (should) have been unethical for any MD to be involved in any such future studies.”
From the abstract:
What is already known on this topic:
The traditional diet-heart hypothesis predicts that replacing saturated fat with vegetable oils rich in linoleic acid will reduce cardiovascular deaths by lowering serum cholesterol This paradigm has never been causally demonstrated in a randomized controlled trial and thus has remained uncertain for over 50 years Key findings from landmark randomized controlled trials including the Sydney Diet Heart Study and the Minnesota Coronary Experiment (MCE) were not fully published
What this study adds:
Though the MCE intervention lowered serum cholesterol, this did not translate to improved survival Paradoxically, MCE participants who had greater reductions in serum cholesterol had a higher, rather than lower, risk of death Results of a systematic review and meta-analysis of randomized controlled trials do not provide support for the traditional diet heart hypothesis